Ryan Jones has suffered a new injury setback and is ruled out of making his comeback against Ulster on Friday.
Harlequins captain Chris Robshaw is ready for the challenge presented by the Heineken Cup.
The Ospreys joined Glasgow at the top of the RaboDirect PRO12 table after a 43-26 victory over Connacht in Galway.
Ospreys welcome back Justin Tipuric for their clash with Connacht, while Paul O'Connell is named on Munster's bench.
Ospreys star Tom Smith looks set for another lengthy spell on the sidelines after injuring his knee against Edinburgh.
The unbeaten Ospreys scored six tries as they powered to a 44-10 RaboDirect PRO12 victory over Edinburgh in Swansea.
Geoff Cross and Aleki Lutui will start their first Edinburgh match of the season against Ospreys at the Liberty Stadium.
Ospreys have announced the signing of scrum-half Phil Mack as cover for the injured Rhys Webb and Tom Habberfield.
Dan Biggar snatched a 29-29 draw for the Ospreys in Dublin as reigning champions Leinster let a 10-point lead slip.
Week two of the Pro12 is rounded off on Saturday as Leinster host Ospreys before Treviso travel to face Scarlets.
Wales fly-half Dan Biggar kicked 14 points as the Ospreys ground out a 24-19 RaboDirect PRO12 victory over Treviso.
Ospreys prop Dimitri Arhip has been ruled out for up to six months after suffering a ruptured Achilles tendon.
We preview the new season and Paul Wallace gives his verdict on the teams in the RaboDirect PRO12.
Ospreys hooker Scott Baldwin has signed a new long-term contract with the club ahead of the RaboDirect PRO12 season.
Ospreys' Joe Rees is targeting an injury-free campaign after he missed most of 2012/13 season following neck surgery.
Ospreys have bolstered their numbers ahead of the new season with the addition of Fijian utility back Aisea Natoga.
Wales hooker Huw Bennett has retired after giving up in his bid to recover from a long-term Achilles injury.
Ospreys will have to start the new season without their winger Hanno Dirksen.
The Ospreys have appointed New Zealander Chris Gibbes as their new forwards coach for next season.
Ospreys have confirmed the signing of Canada winger Jeff Hassler.