Paul O'Connell made a successful return in Munster's workmanlike RaboDirect PRO12 win over the Newport Gwent Dragons.
Ospreys welcome back Justin Tipuric for their clash with Connacht, while Paul O'Connell is named on Munster's bench.
Dragons hooker Rhys Thomas has been ruled out until next year after suffering an ankle injury.
Dragons continued their fine start to the Pro12 campaign by securing a 23-16 win in a Welsh derby against the Scarlets.
Second row forward Ian Nimmo has signed a loan agreement with London Irish.
Leigh Halfpenny will make his first appearance for Cardiff this season while Munster look to make history in Italy.
A last-gasp penalty by Harry Leonard earned Edinburgh a much-needed win over bogey team Newport Gwent Dragons 16-13.
Round two of RaboDirect Pro12 begins with four Friday fixtures featuring Munster, Cardiff Blues, Ulster and the Dragons.
Lions hero Toby Faletau has been told to "pull his socks up" by the Dragons, amid claims that he is not fit enough.
The Dragons picked up an impressive 15-8 victory over Ulster in their RaboDirect PRO12 opener at Rodney Parade.
Reigning champions Leinster face the Scarlets in one of three RaboDirect PRO12 matches taking place on Friday night.
Newport-Gwent Dragons have suffered a double injury blow with Steffan Jones and Darren Waters both ruled out for months.
We preview the new season and Paul Wallace gives his verdict on the teams in the RaboDirect PRO12.
Newport Gwent Dragons No 8 Toby Faletau has signed a new two-year contract with the club.
Sale Sharks will open their Amlin Challenge Cup campaign at home to 2012 winners Biarritz on 10 October.
Newport Gwent Dragons have received a boost with the news Kingsley Jones has joined its coaching staff.
Promising utility three-quarter Jason Tovey has returned to Newport-Gwent Dragons after leaving Cardiff.
Newport Gwent Dragons have confirmed former London Welsh boss Lyn Jones as their new director of rugby.
Sale and Worcester have been drawn in the same pool for next season's Amlin Challenge Cup.
Jamie Smith and Tonderai Chavhanga are among a number of players leaving the Newport-Gwent Dragons.